Khramova T. The role of metabolic and haemodynamic factors in eyeball subatrofy and hypotension in patiens with uveitis

Object:endogenous uveitis, complicated by hypotension and eyeball subatrophy The purpose: to set the role of metabolic and haemodynamic violations in development of uveitis, complicated by hypotension and eyeball subatrophy, by obtaining new data on the direction and intensity of their changes, based on experimental models studied pathology and clinical research. Methods:Ophthalmic methods, echoscpy, echobiometry, ultrasonic doplerography and biomicroscopy, reoophtalmography, biochemical methods, statistical methods; SonoMark SM 400 M Oftalmo biometr, Sonoline-Si-450, Sonoline Versa-Pro, UMAX ІІ, ReoCom. The experimental models of uveit, complicated by hypotension and subatrophy, are first created, based on trigers influence of arginine of glutamate. Scientific information is complemented of haemodynamic disturbances (decrease of systolic blood flow velocity in the ophthalmic artery, in posterior short ciliary arteries and volumetric blood flow), about of lipid peroxidation activation (increased malon dialdehyde, which occurs on the background of increased ceruloplasmin activity in blood serum in case of eyeball hypotension, without its increase at subatrophy) and also about violation of messenger's functions of biological neurohumor of oxide of nitrogen in patients with uveitis, complicated by eyeball subatrophy and hypotension. The mathematical model of prognosis of flow of subatrophy of eyeball is developed. Results of work are introduced in the Kharkiv regional clinical hospital, centre of ophtalmology diagnostic "ZiR". The sphere of use - medicine, ophthalmology.