Аkimov V. Simulation and prediction of the sensor action of olfactory nanobiosensor based on the GPCR protein molecule.

Object of study is the electrical response to sensor action of a GPCR protein molecule in the one-molecule nanobiosensor. The purpose of research is the development of a theoretical framework for prediction and parametrization of a sensor. Research methods are numerical techniques, the method of elementary impedance network, the homologous modeling of the tertiary structure of protein molecules, the adapted percolation method. Results are: the method of modeling the electric current in the protein molecules is developed, the sensor signal change for three GPCR is predicted, the patterns of thermal fluctuations of the signal native conformation of the rhodopsin molecule are obtained. The results can be used in molecular biophysics and biosensorics.