Goroshko O. Peculiarities of the metabolic adaptation in immature babies with the respiratory distress-syndrome and its disorder correction

The thesis is devoted to the study of one of the actual problem of modern neonatology - improvement of the prevention and the treatment of respiratory distress-syndrome (RDS) in immature newborns based on study of RDS epidemiology characteristics, prognostic value of risk factors, metabolic disturbances of ABC, anaerobic glycolysis, antioxidant system, free radical oxygenation of lipids and poractant alfa and levocarnitin combined intake. There were examined 159 immature babies of the gestational age 24-34 weeks. The monovariant analysis and method "Feature Selection and Variable Filtering" revealed that the most significant risk factors of RDS in babies with LBW, VLBW/ELBW are mother's TORCH-infection, diabetes mellitus and gestation diabetes, hormone prevention absence, low evaluation on Apgar scale at the first minute of life, late gestosis, fetus distress, men sex of fetus and low socio-economic status of the family. It was proved that the combined intake of poractant alfa and levocarnitin diminished risk of RDS development, risk of severe RDS, reduced the terms of the clinical symptoms of disease, normalized the metabolic disturbances, decreased the frequency of RDS complications rate and lethality.