Research object: biological properties of staphylococci: cultural, morphological, biochemical, resistance to antibiotic of staphylococci, sensitiveness to the phages. Aim of the research: define biological properties of actual strains genus of Staphylococcus, perfect the bacteriological diagnostics of staphylococcus infections and define the list of antimicrobial substance for their treatment. Methods: bacteriological, microscopy, molecular genetics, immunological, statistical. Theoretical and practical results: are described species composition and levels of resistance to antibiotics of actual strains of staphylococci, are described biological properties of atypical forms of staphylococci isolated in Ukraine; define a list of antimicrobial drugs for treatment infections of staphylococci; to improve the diagnosis oxacillin resistant staphylococci, including coagulasanegative species, recommended the use of test-system of Slidex MRSA Detection (Biomerieux, France) and and oxacillin resistant Staphylococcus aureus 2708 as a test strain; found that the method of analysis profiles of antibiotic resistance is more effective in determining the phenotypic identity and common origin of strains of staphylococci, as compared with the method of phage-typing; demonstrated the possibility of changes in sensitivity to antibiotics of atypical form staphylococci with reversal of the typical metabolic strain; creation of the author's collection oxacillinresistance strains of staphylococci. Novelty: first shows the current differences in species composition and levels of antibiotic resistance and nosocomial and community-acquired strains of staphylococci; for the first time in Ukraine defined the prevalence of strains of staphylococci resistant to oxacillin, including through the production peniсillinbinded protein 2a; at the phenotypic level, proved the difference in the origin of nosocomial strains of S. aureus and strains of S. aureus, isolated from the nasal passages of medical staff; proved advantage analysis profiles resistance to antibiotics compared with the phage typing in defining the common origin of strains; for the first time in Ukraine, atypical forms of Staphylococcus aureus isolated, showed their morphological characteristics, the possibility of changes of biological properties, including resistance to antibiotics, with the return of atypical forms of the metabolic state of a typical. Degree of introduction: the results of the research were implemented in a form of one a information letter and a patent for utility model. Sphere of the use: medicine, microbiology.
