Senko J. Effectiveness of natural surfactant phospholipids in the complex treatment of destructive pulmonary tuberculosis

Object of research - destructive pulmonary tuberculosis (DPTB); goal - improvement of efficacy of treatment in patients with DPTB on the basis of application of natural surfactant phospholipids (NSPh); methods - clinical, radiological, microbiological, fibrobronhoskopy, brush-biopsy, cytology, statistical; novelty - to establish the frequency and nature of bronchial lesions in patients with multidrug resistant destructive pulmonary tuberculosis (MRTB) - 60.0% of patients with MRTB had the endobronhitis with infiltration and ulceration of the bronchial wall; to established that in patients with concomitant bronchial tuberculosis treatment efficiency on 21.4% lower with the terms of healing of cavities; studied the dynamics of pathological changes in the bronchi in patients with DPTB by the application of endobronchial infusion of NSPh - the complete or partial resolution of infiltrative changes in the walls of the bronchi in 100.0% of patients, which improves drainage function of bronchi. The established efficacy of NSPh in the complex treatment of patients with DPTB. The overall treatment combination therapy is effective in 96.7% patients, and standard chemotherapy - in 76.7% of cases. The good tolerance of NSPh with endobronchial administration in patients with DPTB was established. Range of application - medicine.