Volodicheva Y. Differential treatment of duodenal ulcers on the bases of susceptibility H.pylori to antimicrobial drugs.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U000001

Applicant for

Specialization

  • 14.01.36 - Гастроентерологія

22-12-2011

Specialized Academic Board

Д 26.003.09

Essay

The dissertation is dedicated to optimization of treatment of patients with Hp-associated duodenal ulcers on the bases of investigation of susceptibility H.pylori to antimicrobial drugs (5-nirtoimidazole, clarithromycin). Resistance to metronidazole was found in 47,8 %, to ornidazole - 33,3 %. Cross resistance H.pylori to metronidazole and ornidazole doesn't exist in all cases. Resistance to clarithromycin was found in 10,1 % of H.pylori strains. We studied the efficiency and safety of different anti-Helicobacter regimens. High eradication level was achieved by using second line 10-days levofloxacine-based triple therapy.

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