Psaryeva I. Clinical, diagnostic and prognostic value of inflammation biomarkers in patients with ulcerative colitis

The dissertation is devoted to improving the diagnosis of nonspecific ulcerative colitis (UC) by comparative assessment of the informative value of non-invasive biomarkers of inflammation and determining the risk group for an unfavorable course of the disease. Gender analysis of the level of inflammation biomarkers in UC showed that the levels of fecal calprotectin and myeloperoxidase in feces increased in all patients, regardless of gender, while the content of α1-antitrypsin in feces is increased mainly in men. It was found that increased levels of fecal biomarkers of inflammation are associated with bacterial contamination of the small intestine. As a result of statistical calculations, fecal myeloperxidase has the greatest diagnostic value in detecting pronounced UC activity (sensitivity 92.9%, specificity 76.0%) and fecal calprotectin (sensitivity 63.2%, specificity 71.4%). The prognostic criterion for the unfavorable course of UC in a patient with severe activity is the level of fecal myeloperoxidase over 14250 ng/g (OR=30, p<0.001). According to the results of the study, a diagnostic algorithm was developed for non-invasive assessment of the activity of ulcerative colitis and for predicting the course of the disease, taking into account the patient's gender and the level of inflammation biomarkers.