Yakhnytska M. Features of electrolyte metabolism in patients with gastroesophageal reflux disease

The dissertation is devoted to the development of early non - invasive diagnosis of gastroesophageal reflux disease on the basis of new scientific data on clinical and laboratory features of changes in concentrations of saliva electrolytes in this category of patients. The aim of the study was to study the prevalence of erosive esophagitis and features of clinical course of gastroesophageal reflux disease (GERD) in the Lviv region, to investigate electrolyte and pepsin metabolism in saliva, gastric juice and blood, to analyze correlation correlations in the correlation correlation justify the feasibility of determining the concentration of saliva electrolytes for screening for GERD. For this purpose, according to the inclusion criteria, 122 patients were selected who agreed to participate in the study and were divided into groups: 102 individuals with GERD and 20 practically healthy subjects who were included in the control group. In patients without esophagitis, calcium levels were found to correlate with daily heartburn and bad taste, whereas nausea correlated with salivary sodium levels. In patients with endoscopically positive disease, salivary calcium levels correlated with recurrent heartburn and epigastric pain, and sodium levels correlated with belching. The above indicates the feasibility of studying electrolytes and pepsin saliva for screening diagnosis of GERD, control of pharmacotherapy in this category. ill.