Mykhaylo A. Functionalized 1-arylpyrazoles based on diazonium salts: synthesis, transformations and biological activity

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U000156

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

26-12-2011

Specialized Academic Board

Д.35.052.01

Essay

The aim of this thesis was to develop new methods for the preparation of 1-arylpyrazole derivatives. The scope of the Japp-Klingemann reaction leading to 1-arylpyrazoles was extended. An efficient method of synthesis of ethyl 1-aryl-4-formyl-1H-pyrazole-3-carboxylates was developed. Ethyl 4-acetyl-1-aryl-5-methyl-1H-pyrazole-3-carboxylates and ethyl 1,5-diaryl-4-cyano-1H-pyrazole-3-carboxylates were also prepared.

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