Kornet M. Biological activity of derivatives S-(quinoline-4-yl)-L-cysteine and their structural analogs

Derivatives S-(quinoline-4-yl)-L-cysteine and their structural analogs (deamination analogs - b-(quinoline-4-yltio)-propionic acid, decarboxylation analogs - S-(quinoline-4-yl)-cysteamine). Studying of influence on display of biological activity and toxicity presence or absence carboxy and amino groups in a molecule cysteine. The Pass-analysis, chemical synthesis, the element analysis, thin layer chromatography, NMR Н1- spectroscopy, chromato-mass spectrometry, research of antibacterial action, phytotoxicity, lethal dose, antiradical, antioxidative, analgesic, antineoplastic, radioprotective, growth regulatory activities. Influence on level of toxicity of various chemical modification in a structure of derivatives S-(quinoline-4-yl)-L-cysteine and their structural analogs on different taxonomic groups (a bacterium, plants, mammal) is studied. It is researched their antiradical, antioxidant, analgesic, antineoplastic activities, growth regulatory and radioprotective activities and the dependence institution "a chemical structure - biological action" were done. This compound express preventive antioxidant action. Sphere of use - bioorganic chemistry.