Sergienko K. Clinical and echocardiographic variants of cardiac remodeling in children with cardiomyopathy

The thesis is devoted to improve the diagnosis of diseases of the myocardium in young children by exploring the features of the course, outcome, and myocardial remodeling options and determine the prognostic criteria of myocardial dysfunction based on clinical and instrumental examination at follow-up. The usefulness of in-depth survey of cardiac patients who are at an early age suffered myocardial disease was proved, even in the absence of clinical signs and complaints about violations of the cardiovascular system or heart failure. The outcomes of myocardial disease in children were studied. We have revealed the features of the disease at the time of disease manifestation and in catamnesis. Studied rates of biochemical markers of myocardial damage and latent chronic heart failure (troponin I, CFC, LDG, brain natriuretic propeptide of B type).The data of Doppler echocardiography was analyzed to determine the types of myocardial dysfunction and cardiac remodeling options at the onset of the disease and in catamnesis. An algorithm of diagnostics of myocardial dysfunction in catamnesis and algorithm of diagnostics of myocardial diseases adverse outcome were suggested and can be applied at all stages of the monitoring of patients. We have found that patients with non-rheumatic myocarditis dominate among children with pathology of the myocardium, with onset at an early age. The most unfavorable course and outcome was observed in patients with Dilatated Cardiomyopathy and Endocardial fibroelastosis. When diseases attack the children at the beginning of their demonstrations there are different types of cardiac remodeling, and the most unfavorable among them is the eccentric type.