Nadtochii T. Clinical-paraclinical and morphofunctional features of inflammation in children with nonspecific respiratory diseases, depending on periods of illness and methods of correction therapy.

The dissertation is devoted questions of optimization of differential diagnostics and treatment of nonspecific diseases of respiratory organs at children. In case of a subacute, flaccid current of inflammatory process in respiratory tracts, especially in the presence of an obstructive syndrome, there are difficulties of differential diagnostics with a bronchial moderately severe asthma. The relapsing current of a bronchitis, its frequent repeatability frame difficulties directed by diagnosis recurrent or chronic bronchitis. Difficulties are bound by that clinical picture chronic bronchitis at children and adults differs. For the best understanding of the anamnestic and clinical data the ball estimation of results of inspection is offered. For the purpose of diagnostics perfection methods of cytological, immunocytochemical and elektronno-microscopical studying of structure of an epithelium of bronchial lavage are used also. As additional criterion at statement of the diagnosis and control of efficiency of rehabilitational actions the conducted research of amino-acid structure of a condensate of the exhaled air, displaying important not respiratory function of lungs serves for the first time. Established cytologic and immunocytochemical disturbances regeneration processes in an epithelium of bronchi, depending on clinical implications of disease, and also ultrastructural criteria of damage of a mucosa of bronchi of children with chronic inflammatory diseases of respiratory tracts also are developed criteria which can be used at selection of methods of treatment of children with chronic and relapsing inflammatory diseases of respiratory organs. The taped disturbances in a condition of humoral and cellular immunity at patients with nonspecific inflammatory processes in respiratory tracts, prove requirement in immunoregulation at such patients. Us it is offered probiotics and complex of biologically active substances which promoted more positive dynamics of a condition of patients and immunity indicators in comparison with patients only on base therapy.