Ganzha O. Determination of radiosensitivity in terms of body nonspecific resistance

The dissertation is devoted to the study of individual radiosensitivity of mammals' organism (rats, mice) as a nonspecific reactions-responses to stress agents of different nature (hyperthermia, immobilization, ionizing radiation). It is established that the dynamics of oxidative metabolism after the action of stress agents reflects the radiosensitivity of the organism. It is revealed that the main indicators of oxidative metabolism that characterize the organism radiosensitivity, is the level of prooxidant-antioxidant ratio, catalase activity, the content of lipid peroxidation products. Radioresistant animals are characterized by low values of output parameters of oxidative metabolism. These animals inherent in earlier (compared with radiosensitive) restore of the intensity of free radical processes. It is found that radioresistant animals are characterized by a gradual decrease in activity and intensity of catalase and peroxidation processes in the peripheral blood in response to stress agents. It is established that the dynamics of indicators of oxidative metabolism by the action of thermal and immobilization stress for animals with different radiosensitivity is similar to reaction-response after irradiation. Developed approaches of individual radiosensitivity determination were confirmed in studies on lines of mice that are genetically characterized by different radiosensitivity, and modification of radiation effects by preparation with antioxidant properties.