Petrusha Y. Biological activity of S-geterilderivates of thioacids

S-geterilderivates of thioacids. Search of new effective low-toxic bioregulators among S-geterilderivates of thioacids, research of their physical, chemical and biological properties, dependence establishment between chemical structure and biological action. Studying of influence on display of biological activity and toxicity of replacement of heterocyclic system in a molecule. The PASS-analysis, chemical synthesis, the element analysis, a thin-layer chromatography, NMR H1-spektroskopy, IR-spectroscopy, chromatography-mass spectrometry, research of antimicrobic action, cytotoxicity, sharp toxicity, antiradical activity, nootropic and antidepressive action. Influence on toxicity level of replacement of heterocyclic system in a molecule of S-geterilderivates of thioacids on different taxonomic groups (a bacterium, plants, mammal) was studied. It was investigated nootropic and antidepressive properties of substances and it was established dependence "chemical structure - biological action". At replacement of heterocyclic system in a molecule of similar substances increased toxicity of substances among pyridine - tetrahydroacridine - acridine. Existence of antiradical activity of the synthesized substances was defined. On the mechanism of action they can be considered as "trap" of free radicals. It was revealed among S-geterilderivates of thioacids of substance with bacteriostatic, nootropic, antidepressive and growth-stimulative action. The leading structure - di-Na-salt of 2-(pyridine-4-iltio)succinic acid which has the expressed cerebroprotection activity with the antioxidant mechanism of action was found. It was nontoxic, has the expressed antioxidant, antihypoxemic, antidepressive, neuroprotective and nootropic properties. Sphere of use - bioorganic chemistry.