Lukashuk I. Prediction of the efficiency of somatotropic insufficiency treatment with growth hormone in prepubertal children

Object of the study: the functional state of the hypothalamic-pituitary axis in prepubertal children with somatotropic insufficiency (SI). Aim of the study: to optimize the treatment of pubertal children with SI through the development of scientifically based diagnostic technology and prediction of the effective therapy with recombinant growth hormone (rGH) considering the growth response (GR). Methods of the investigation and equipment: clinical, biochemical, hormonal, instrumental, statistics; analyzer “Immulite 2000 XP”, stadiometer “Sistem Dr. Keller J.”, tomograph “Siemens Magneton Impact”. Theoretical and practical results: new positions that expand the existing ideas concerning diagnostic and prognostic values of these parameters in SI of prepubertal children were based on the studying basal auxologic, biochemical and hormonal parameters and growth response for the 1st year of rGH therapy. The prognostic alg orithm and prognostic chart of the growth response to rGH therapy for children with SI, that will identify children with low GR were developed and implemented. Novelty: for the first time, actual growth response for a 1-year of rGH therapy in prepubertal children with basal auxologic, and hormonal parameters was estimated; GR predictors to rGH therapy were determined and prognostic table based on basal parameters was developed. Degree of introduction: the results of investigations were implemented in the work of children's hospitals in Ukraine, as well as educational process of the Departments of Endocrinology, Pediatrics N 4 and N 5 in the O. O. Bogomolets NMU and the Department of Endocrinology in the P. L. Shupik NMAPE. Field of application: endocrinology, pediatrics.