Andryushina O. Synthesis and properties biologically active folat-containing polyurethaneureas

The subject of research was development of new biologically active folat-containing polyurethaneureas. The aim of the work was development of polymer systems based on the macrodiisocyanate, diamines, namely, 1,6-hexamethylenediamine, 4, 4'-diaminodiphenilmetan. Properties of polymer film-type materials were investigated. Key data were obtained by meaus of the following methods: NMR- spectroscopy, infrared spectroscopy, X-ray structural analysis, thermogravometric analysis, differential scanning calorimetry. Using a model reaction between folic acid and phenyldiisocyanate the chemical immobilization was proved to occur through primary amino groups of folic acid. It was shown, that polyurethaneureas containing folic acid possessed an enhanced durability to biodegradation in simulated body fluids. In order to study the dynamic release of the folic acid in vivo a novel spectrophotometer technique was used. It was shown that FA release period may be controlled by changing the molar ratio of diamine and immobilized folic acid. Due to medical-biological investigation was established that folat-containing polyurethaneureas were biologically active and biocompatible film-type materials that may be wide used for wounds and burns treatment.