Kryvenko E. Patients with have features of products of interleikyns, selectins and molecules of аdhesia a chronic glomerulonephritis

The paper presented the findings on examination of changes levels of proinflammatory cytokines (TNF-alfa, IL-1beta and IL-17) in serum and supernatants by spontaneous and stimulated PHA production in patients with chronic glomerulonephritis, as no indication of morphological forms, and depending of proliferative and nonproliferative forms. The data indicate significant increase in levels of TNF-alfa, IL-1beta and IL-17 in patients with chronic glomerulonephritis when compared with the control group. Mean values of TNF-alfa and IL-1beta significantly higher in patients with proliferative forms, indicating a more pronounced damage renal tissue. The results change levels of adhesion molecules in patients with chronic glomerulonephritis show significant increase averages VCAM-1 as in patients with chronic glomerulonephritis without indication of morphological forms, and in patients with proliferative and nonproliferative forms. Levels of VCAM-1 in patients with nonproliferative forms of chronic glomerulonephritis with higher levels. Levels of E-selektynu slightly altered and in comparison groups did not show significant difference. In patients with chronic glomerulonephritis, depending on the second and third stages of chronic kidney disease was defined by increased levels of TNF-alfa and IL-17 and IL-1beta levels were not significantly different from the healthy individuals. When comparing groups were seen lowering TNF-? in the group of patients with stage III CKD and average IL-1alfa and IL-17 had no significant difference. It was also determined a significant increase in levels of VCAM-1, as in group II and in group III stages of CKD, and in comparison groups observed its increase in patients with stage III CKD. Average E-selektynu when compared with groups II and III stages of CKD significant difference is found, as well as when compared with the control group.