Lenga V. Clinico-metabolic abnormalities in children with not diabetic ketosis against acute diarrheas and methods of their correction

The dissertation devoted studying of frequency of occurrence not diabetic ketosis and clinico-metabolic infringements at its development against invasive and secretory diarrheas at children on an example shigellosis and rotavirus infection, optimization of pathogenetic treatment.It is shown that frequency of occurrence not diabetic ketosis at children against shigellosis and rotavirus infection took place in 26,8 % and in 69,9 % of cases accordingly. Clinical features of shigellosis and rotavirus infection flow are found at children depending on presence or absence not diabetic ketosis. It is shown that at not diabetic ketosis occurrence against infectious diarrheas the metabolic infringements displayed by substantial growth in whey of blood of these children in comparison with children without not diabetic ketosis and control bunch of uric acid levels and protein oxidative modification products levels of a blood plasma go deep (in 1,37 and 2,14 times accordingly). The predictors of occurrence not diabetic ketosis in children act a slow phenotype of acetylating and ternary association erythrocyte antigens B(III) P(+) N. Use along with standard therapy and the proof-reader of the energy balance trimetabol and silics authentically reduces duration of temperature reaction, vomiting, carrying out terms of intravenous drug administration and hospitalization, promotes authentically to faster normalization of levels of uric acid and carbonyl derivatives.