Baudarbekova M. Atypical hyperplasia and adenocarcinoma of endometrium: pathohistologic and immunohistochemical differential characteristics

Proceeding from the results of pathomorphological, immunohistochemical analysis and computer morphometry it has been detected that complex atypical hyperplasia of endometrium is characterized by higher level of bcl-2, р21WAF1 and caspase-3 expression than simple atypical hyperplasia, but levels of estrogen receptors, progesteron receptors and Ki-67 expression are the same. It was proved the cross-correlation expressed direct connection of level of expression of estrogen and progesteron receptors by the cages of glandular-fibrotic polypus and base-line endometrium, and also a moderate line cross-correlation connection between expression of Ki-67. Non invasive adenocarcinoma of endometrium differs from complex atypical hyperplasia with the higher level of p53, р21WAF1 and caspase-3 expression, and positive expression of MMP-9 and TIMP-1. It was detected that invasive adenocarcinoma differs from non invasive adenocarcinoma of endometrium by higher level of estrogen receptors, р53 and caspase-3 expression and level of bcl-2 was lower. In the zones of invasion of adenocarcinoma it was found high and moderate level expression of VEGF, the biggest quantity of CD34-positive microvessels and the highest expression of ММР-9 in tumors epithelial and stromal cells. The cross-correlation expressed direct connection of level of expression of ММР-9 and area of CD34-positive microvessels was proved.