Vasylenko A. The influence of geometric, adsorption and chemical modification of high-dispersed nanosized silica on the adsorption of gelatin

The thesis is devoted to the study of the interaction of gelatin and BSA with modified nanosized silica (nanosilica). For the synthesis of modified nanosilica samples the mechanical and hydrothermal treatment as well as the adsorption from gas and water media were used and the reactions of nanosilica with hexamethyldisilazane was carried out. It is shown that the geometric modification of nanosilica can change the size of its primary particles and secondary formations. This process ultimately determines the protein adsorption properties of the sorbent. We found that in the case of adsorption modification the protein adsorption properties of the nanosilica samples are determined by the structure modifier and the degree of the adsorbent modification. It is established that the adsorption of gelatin on the nanosilicas surface with different degree of hydrophobization depends strongly on the experimental conditions, particularly on the relationship alcohol- water in equilibrium solution. On the example of gelatin it is revealed that the main factors determining the protein adsorption properties of the modified nanosilica are its morphology of its particles and the nature of the surface active centres. Their changes can not affect or can reduce the adsorption nanosilica ability up to its vanishing; this must be considered in creating the new dosage forms and combination preparations based on it.