Balabantseva G. Laryngopharyngeal and pulmonary manifestations of gastroesophageal reflux disease: optimization of diagnostic and therapeutic strategies.

In the dissertation submitted for Theoretical synthesis and reach practical solving scientific task, which is to improve the diagnosis of laryngeal and bronchopulmonary manifestations of GERD and clinico-pathogenetic substantiation prolonged use double doses of PPIs to improve treatment ekstraezofahealnyh manifestations of GERD. To optimize the diagnosis of laryngeal and bronchopulmonary manifestations of GERD in clinical practice should be widely used modified 2-week test with double-dose PPI, which demonstrates sufficient diagnostic information content. In doubtful cases to diagnose for verification LFR should apply daily hipofarynhealnyy pH monitoring.Patients with reflux laryngitis for treatment efficacy from the very beginning is advisable to appoint a double dose PPIs (rabeprazole 20 mg twice a day 30 minutes before meals) for at least 3 misyatsiv.Pry the linked of asthma and GERD all patients to eliminate reflux symptoms improve control of symptoms and the frequency of nocturnal attacks of asthma, and to improve respiratory function should be in addition to basic therapy administered pantoprazole 40 mg twice daily for 3 months.