Lebid' O. Transamination reaction of 1-alkyl-3-(alkyl)aminopyrrole-2,5-diones

The thesis is devoted to study of transamination of 1-alkyl-3-(alkyl)aminopyrrole-2,5-diones by aliphatic and aromatic amines, hydrazine and hydroxylamine derivatives in the presence of different acid catalysts and without them. Optimal conditions of these reactions developed, their regularities have been explained. The mechanisms of transamination have been investigated by chemical and computational methods. Electron-withdrawing properties of alkyl groups have been detected on the basis of quantum-chemical computations of 3-aminopyrrole-2,5-dione derivatives. This observation has been confirmed by quantum-chemical investigations of ammonia and methylamines. It has been proved that the basicity of amines in the gas phase is determined of energy of nitrogen lone electron pare and isn't dependent of the negative charge, the total electronic population and population of lone electron pare of nitrogen atom.