Voitenko O. Formation of ultradispersed silver phases in the microbiological matrices

The thesis is devoted to study of regularities governing the formation of ultradispersed silver phases in cell matrices belonging to different taxonomic groups of microorganisms under the influence of physical and chemical factors. A new chemical and microbiological method for the colloid silver phase synthesis in microorganism matrices was developed. An average particle size was of 1.6-1.7 nm in the yeast matrix and 2.1-2.5 nm in bacilli, pseudomonade, and colibacillus cells. In the cell wall, nanoparticles formed the chain aggregates having a size comparable to the cell radius. It was shown that low-intensity pulsed electric field could serve an effective tool in the modulation of cell hydrophilic-hydrophobic characteristics and metal ions bioaccumulation. The activation nature of the pulsed field effect on cell hydrophobicity and a silver nanophase formation in microbial matrix was revealed. The bactericidal and fungicidal properties of bionanocomposite materials versus on the biomatrix composition, the phase-disperse properties of silver particles, and their contact surfaces were investigated. The compositions with antibiotics form active slow-release drugs that have a synergistic effect when combined. A patent of Ukraine for utility model protects the compositions.