Zadorozhniy A. Thiophenic isosteres of modified alkaloid glycosminine

The theses are devoted to study of heterocyclization reactions on the base о-cyanomethylbenzoic acid and thiophen isosteres of antranilic acid, determination regularity of their passing, development novel preparative methods of synthesizing fused and unfused pyrimidinone derivatives, containing carboxylic group, investigation routes of their next modification. Determination regularities passing reactions of reductive Raney nickel desulphurization corresponding positional isomeric 2-(4-оxо-3,4-dihydrothieno[m,n-d]pyrimidine-2-yl-methyl)benzoic acid has been permitted by modification such parameters as temperature, type of solvent and ratio of reagents, essentially influence on yield of destination products.