Shamray I. The features of treatment and prophylaxis of recurrent forms of acute bronchitis in children with central nervous system perinatal lesions

The thesis is devoted to improving the effectiveness of the treatment and prevention of acute bronchitis recurrent forms (RB) in children with perinatal lesions of the central nervous system (CNS PL) in anamnesis. In children with CNS PL the course of RB is accompanied by severe violation of secretor and respiratory tract evacuation mechanisms, increased fatigue, lack or low severity of fever, increased swelling of the nasopharynx, a prolonged course of rhinosinusitis, the presence of adenoid vegetations. In the period of physical well-being in children with PL of central nervous system and RB increase in the number of pathogenic microorganisms, the content of serum CD25 lymphocytes, IgM, tumor necrosis factor (TNF-?) and interferon-? (IFN-?), the final stable metabolites of nitric oxide (FSM NO) were defined as well as the decrease of sIgA concentration in the saliva, vasoactive intestinal peptide (VIP) in the serum. In acute bronchitis in children with RB and CNS PL an increase of the CD25 lymphocytes number, the content of IgM, TNF-? and IFN-?, FSM NO, substance P in serum, reducing the concentration of sIgA in saliva, serum VIP were found. Using the developed schemes of therapy and rehabilitation and prevention activities allowed in children with RB and CNS PL to reduce the incidence, duration and severity of the acute stage of bronchitis, reduce the number of bacterial complications and antibiotic use.