Chernenko L. State of proteinase-proteinase inhibitor system and FNT- ? in children with bronchopulmonary dysplasia.

The thesis was devoted to problems of studying the factors which are referred to an improvement the estimate objectification of bronchopulmonary dysplasia course in children on the basis of definition the state of proteinase-proteinase inhibitor system and levels of anti-inflammatory cytokines. Peculiarities of clinical course of bronchopulmonary dysplasia in children at the present stage which are characterized by presence of disharmonious physical development, signs of undifferentiated dysplasia of connective tissue, abnormalities of the functional state of cardiovascular system and digestive organs, symptoms of bronchiolitis during an exacerbation and symptoms of bronchial obstruction and respiratory insufficiency irrespectively to disease duration have been defined. The presence of an imbalance in proteinase-proteinase inhibitor system which has peculiarities at different forms of disease was become clear. It was positioned that increasing activity of proteinases of vasoconstrictive, apoptogenic and destructive action results in to strengthening the fibrous processes of pulmonary parenchyma, and can be recognized as prognostically unfavorable factor of bronchopulmonary dysplasia course. A pathogenetic significance of the increased levels FNT- ? and IL-1? in the induced sputum was outlined in an undulating course of chronic inflammation of respiratory tracts and the expediency of definition of an expression the indicated anti-inflammatory cytokines for an estimate of therapy efficiency and terms of inhalation corticosteroids application in children with bronchopulmonary dysplasia have been proved. Interconnections between clinical and biochemical indicators were analyzed and the scientifically based mathematical model of forecasting the unfavorable outcome of bronchopulmonary dysplasia which has high self- descriptiveness and reliability was developed.