Viatchenko-Karpinski V. Modulation of functioning of P2X3-receptors by analogues of diadenosine polyphosphates in rat sensory neurons upon painful syndromes

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U003744

Thesis Registration Form

0413U003744.pdf

Applicant for

Viatchenko-Karpinski Vyacheslav

Specialization

03.00.02 - Біофізика

Date of defense

11-06-2013

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

The present study revealed the role of P2X3 receptors in development of different painful syndromes and modulation of these receptors functioning by analogues of diadenosine polyphosphates. We have determined that analogues of diadenosine polyphosphates are stable and selective agonists of P2X3 receptors, and have no effect on other P2X purinoreceptor subtypes. Analogues of diadenosine polyphosphates dramatically decreased amplitudes of currents, which were mediated by functioning of P2X3 receptors. Simultaneously they effectively decreased thermal hyperalgesia and number of nociceptive responses during chronic noninflectional inflammation.

Thesis supervisor

Voitenko Nana V.

Official opponents

Соловйов Анатолій Іванович
Жолос Олександр Вікторович,

Files

Aref.doc

Diss.doc

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