Petrashenko V. Energy and microelements ensuring of premature infants with hypoxic damage of central nervous system.

The thesis is devoted to improving of diagnosis of perinatal hypoxic damage of CNS in premature infants with low and very low birth weight and prognosis of this disease in the acute period by the way of studing of energy and microelements ensuring during neonatal period. It was found that hypoxic damage of CNS in premature infants leads to the disbalance of microelements (Zn, Cu, Fe), the severity of which deepens with the decreasing of body weight and increasing of the severity of damage of CNS. In newborns with low and especially with very low birth weight perinatal hypoxic damage of CNS leads to the significant damage to cell membranes and penetration to the blood NSE, using the concentration of which it is possible to predict the formation of destructive changes in the brain. Perinatal hypoxic damage of CNS in children is accompanied by disorders of energy ensuring, which shows as a decreasing of morphometric parameters of SDG activity of peripheral blood lymphocytes along with the activation of anaerobic glycolysis and increasing in serum LDH, depending on body weight and severity of hypoxic damage. It is suggested in premature infants with low and very low birth weight to determine the serum level of NSE, LDH and morphometric parameters of SDG activity of peripheral blood lymphocytes, amount of microelements (iron, copper and zinc) in serum, erythrocytes and urine at 3-7 and 20-30 days of life for early diagnosis of perinatal hypoxic damage of CNS and prognosis of this disease in acute period