Masliy S. Rationale for the use of angiotensin II receptor blockers and antihypoxants in patients with atrial fibrillation and comorbidities.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U005167

Thesis Registration Form

0413U005167.pdf

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

25-06-2013

Specialized Academic Board

Д 58.601.02

Essay

The present study addressed the issues of cardiac structure and function in different forms of atrial fibrillation, characteristics of clinical course of atrial fibrillation, predictors of complications and survival of patients with comorbid coronary artery disease (myocardial infarction and postinfarction cardiosclerosis), arterial hypertension, and chronic obstructive pulmonary disease. The role of hyperuricemia, disorders of lipid and electrolyte metabolism, changes of heart rate variability in patients with atrial fibrillation was established. The application of Cox proportional hazard models permitted to determine the predictors of atrial fibrillation recurrence after restoration of sinus rhythm. A multifactorial prognostic model for assessment of atrial fibrillation recurrence risk was created. Differential approaches to management of patients with atrial fibrillation with the use of an angiotensin II receptor blocker olmesartan, and an antihypoxant quercetin were proposed. Their clinical effectiveness was proved.

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Files

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dis.doc

dis.doc

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