Breslavets Y. Faktors of aggression and resistence of stomach mucous membrane in patients with NSAID-gastropatyes and the ways of their correction

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U005270

Applicant for

Specialization

  • 14.01.36 - Гастроентерологія

09-09-2013

Specialized Academic Board

Д 08.601.02

State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine"

Essay

The dissertation is devoted to improvement of diagnostics and treatment of patients with NSAID-gastropaty. There was performed the complex study of clinical signs, endoscopical, histological and immunohistochemical parameters iNOS, eNOS, COX-2 in the mucosa of the gastroduodenal zone, interrelations between them that have the main importance in mechanism of development of NSAID-gastropaty. On the ground of complex investigation there was formed the concept of pathogenic mechanisms of NSAID-gastropaty with due regard for the extent selective NSAID, presence of Helicobacter pylori, acid-producing function of the stomach, content COX-2, eNOS, іNOS in the mucosa of gastroduodenal zone.

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