Dobroskok V. Optimization of the medical treatment of children suffering from acute suppurative inflammatory diseases of the maxillofacial area.

The thesis is dedicated to the issue of increasing the efficiency of multimodality therapy for children suffering from acute suppurative inflammatory diseases of the maxillofacial area considering the malfunction of the cytokine profile at the level of both organism and oral cavity. The results of the thesis are based on the physical and laboratory examinations of 169 children suffering from acute suppurative lymphadenitis of different topographical and anatomical focalization and of 61 patients suffering from acute odontogenic osteomyelitis of the body of mandible. There were ascertained the increase of the caries intensity and the oral cavity's sanitary condition deterioration that was clearly defined in osteomyelitis by virtue of stomatological status examination for the moment of hospitalization. Taking into consideration a certain insufficiency of the results obtained after medical treatment according to the report of delivery of health care for the given categories of patients, to increase the efficiency of their medical treatment there was pathogenetically grounded the necessity for additional prescription of polyoxidonium involving the sanitary measures for oral cavity care, oral bathes with Lysomucoid and stepwise application of domestic multicomponent ointments. Their inclusion to the multimodality therapy allowed reaching the improvement of the oral cavity sanity status and parodentium tissues, normalizing the amount of mouth liquid output and its qualitative properties, stabilizing the level of pro- and anti-inflammatory interleukins therein and in peripheral blood. It influenced positively the cellular composition of wound exudates and contributed to the acceleration of the decrease of wound surface area by 1,2 times for the period of clinical recovery in both nosological disease forms.