Cherkasova O. Comprehensive treatment of generalized periodontitis in young patients with arterial hypertension.

The thesis is devoted to developing a comprehensive scheme of rationale and effectiveness therapy, which includes beta-adrenoblockers, metabolite and sorption-detoxication drugs, for treatment of generalized periodontitis in young patients with concomitant essential arterial hypertension. In 60 young SHR rats with clearly pronounced arterial hypertension, we studied structural changes in the gums, as well as modifications of such changes in animal groups subjected to pharmacological correction of hypertension (using bisoprolol, thiotriazoline and quercetine). The obtained data are indicative of significant apoptogenic properties of bisoprolol. In this situation thiotriazoline (used with a therapeutic aim) demonstrated significant inhibitory effect with respect to apoptosis and also protective properties. Clinical, laboratory and morphological (light and electronic microscopy of gingival biopsies) study in 75 men (aged 23 to 44 years) determined that the proposed in experimental preclinical study optimization of complex simultaneous treatment of generalized periodontitis and concomitant essential arterial hypertension (with the inclusion of bisoprolol, thiotriazoline and «Syliks») has a positive effect on all clinical characteristics of generalized periodontitis.