Ali M. Endotoxin bounding systems and receptors in patients with chronic obstructive pulmonary disease

Dissertation is devoted to the study of influence of cellular and humoral imbalance endotoxin bounding systems, genetic polymorphisms of Toll-like receptor 4-type markers of systemic inflammation and quality of life in patients with COPD and to the methods of optimization of treatment of patients with this pathology based on herbal extracts of Uncaria tomentosa. Dysfunction of systemic and mucosal antiendotoxin immunity, change of CRP and LBP as markers of system inflammation, genetic polymorphism of Toll-like receptor 4 types, and clinical subtypes of COPD patients with different degrees of antibody responses to endotoixin were studied. Based on these data revealed lower levels antibody response to ET in patients with COPD is characterized by the most pronounced indicators of the severity of respiratory symptoms, activity and impact according SGRQ-C questionnaire, the lowest spirography parameters (FEV1) greater reductions mucosal immunity and serum CRP, LBP in blood and sputum, increased expression of CD14 njt only at monocytes, but at neutrophils too, and lower expressions LPS Fitc receptors on neutrophils and positive clinical and immunological response to treatment of herbal extracts of U.tomentosa. In all patients with COPD most often found in 87.1% of homozygous AA genotype polymorphism Asp299Gly TLR4, without significant differences between clinical groups, suggesting to hyperrespoder cellular response to ET and demonstrates the importance of an adequate function of the ET neutralizing humoral systems.