Abramova N. Disorders of thyroid homeostasis in patients with arterial hypertension and concomitant abdominal obesity and pathogenetic substantiation of their correction based on the genetic factors.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U001701

Thesis Registration Form

0414U001701.pdf

Applicant for

Abramova Nataliia Orestivna

Specialization

14.01.02 - Внутрішні хвороби

Date of defense

22-04-2014

Specialized Academic Board

Д 26.613.06

Shupyk National Medical Academy of Postgraduate Education

Essay

Thyroid and redox system parameters, carbohydrate and lipid metabolism, the functional state of the endothelium, depending on body mass index and polymorphisms of deiodinase type 1 (DIO1) and glutathione peroxidase type 1 (GPX1) genes have been studied in 121 patients with essential hypertension and abdominal obesity. An association of thyroid homeostasis disorders with C/T polymorphism of DIO1 and Pro197Leu polymorphism of GPX1 genes has been established. Efficiency of sodium selenite application in correction of thyroid homeostasis disorders and optimization of carbohydrate and lipid metabolism, redox system and endothelial function in patients with hypertension and abdominal obesity have been proved.

Thesis supervisor

Pashkovska Natalya Victorivna

Official opponents

Бойчак Михайло Петрович
Паньків Володимир Іванович

Files

aref.doc

dis.doc

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