Garmash O. Clinically experimental substantiation of methods for correcting periodontal tissue microcirculatory disorders in patients with the intrauterine growth restriction syndrome in past history.

The dissertation aims to increase the efficiency of preventive methods for correcting microcirculation disorders in periodontal tissues of patients with the intrauterine growth restriction (IUGR) syndrome in past history. The retrospective statistical and epidemiological analyses of the dental status of patients who had the intrauterine growth restriction syndrome in their past history have revealed a negative dynamics in the prevalence of dental diseases with age. The greatest violations of dentition are revealed to be related to the "symmetric" (hypoplastic) type of this pathology. Test animal studies have revealed that the intrauterine growth restriction is accompanied by the injury of the microcirculatory bed of periodontal tissues, vascular density, and discirculatory disorders, which lead to ischemia area formation, the appearance of necrobiotic foci, and as a result, to the initiation of sclerosis processes. Also the metabolic inhibition of nitric oxide arises along with the inhibition of endothelial NO-synthase fractions and the activation of inducible NO-synthase fractions. A comparison of the effectiveness of the exposure of the vascular tone of the periodontal tissues to a low-intensity polarized polychromatic light with the exposure to monochromatic red semiconductor laser emissions (658 nm) with regard to the changes in the nitric oxide concentration in the composition of the oral fluid has been performed. Improvement of the biochemical composition of the oral fluid is observed in the majority of patients in both groups (56 % - 75 %). A little better effect is observed in patients after laser therapy sessions. Recommendations to apply a preventive method depending on the crystal-forming properties of the oral fluid are given.