Zdoryk I. Cognitive impairment in women who suffer from depressive disorders comorbid with hypertension

This thesis raised the problem of improvement diagnostic help and therapy for patients with cognitive impairment and depressive disorder associated with essential hypertension. Major psychopathological syndromes were presented anxious-depressive (54,9 %), asthenic-depressive (37,3 %) and depressive-hypochondriacal (7,8 %) variants. Clinical diagnoses were responsible rubrics of ICD-10: F06.32 mood disorder due to known physiological condition with major depressive-like episode (51 %), F43.2 adjustment disorder (29,4 %), F34.1 dysthymic disorder (15,7 %), F32 major depressive disorder, single episode (3,9 %). HDRS score was 15,41±1,65. Diagnosed high level of state anxiety (62,7 %) and trait anxiety (63,7 %). Cognitive impairment was observed in 92 women (90,2 %) and characterized by decrease in the volume, strength and focus of attention, the ability to switch deterioration, increased distractibility, difficulty in mastering new material violations in the areas of visual-constructive and executive functions, moderate memory impairment, reduced capacity for abstraction and generalization. The effectiveness of integrated treatment was 73,6 %. Mood stabilization, reduction of levels of state anxiety and trait anxiety, improving cognitive function was greater in the therapeutic group.