Hussein H. Immunoinflammation, apoptosis in patients with arterial hypertension and diabetes mellitus 2 type.

Dissertation is devoted to early diagnostics efficacy increasing of immunoinflammatory and apoptotic activation on the base of complex assessment of interleukin-18 (IL-18), interleukin-10 (IL-10), apoptosis markers - FasL (CD95L) and FasR (CD95, APO-1) levels, carbohydrates metabolism parameters in patients with arterial hypertension (AH) with concomitant pre-diabetes, diabetes mellitus 2 type (DM 2 type). It was found that proinflammatory cytokine - IL-18 levels were elevated in AH and AH with concomitant pre-diabetes, DM 2 type. Significant correlations between IL-18 and carbohydrates metabolism parameters suggest proinflammatory cytokines involving in glucometabolic disorders in patients with AH. It was detected elevation of anti-inflammatory cytokine - IL-10 content in AH that can be considered as protective reaction to suppress proinflammatory cytokines activity. Patients with AH with pre-diabetes, and DM 2 type were characterized by IL-10 levels reducing. Plasma apoptosis signal molecules levels in AH associated with pre-diabetes, and DM 2 type were significantly higher vs AH without dyglucemia and control group. In patients with AH hyperglycemia promotes apoptosis trigger mechanisms activation. Relationships between glucose levels and plasma circulating apoptosis markers activity in patients with DM 2 type associated AH were established.