Kopernyk I. Prediction and evaluation of antimycotic activity of new azoles and bisphosphonates

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U004038

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

19-09-2014

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

Fungal culture Candida albicans М 885 (ATCC 10231). QSAR predicting and experimental evaluation of antimycotic activity of functional substituted oxazoles and nitrogen-containing bisphosphonates. Computer modeling of the relationship structure - biological activity of chemical compounds, disc diffusion method, method for determining the median effective dose and its error, method of osmotic hemolysis of human blood erythrocytes, Panchenkov's method, tetrazolium nitroblue test. Active compounds were recommended as potential anti-candidal agents. For prediction antimycotic activity of functional substituted oxazoles and nitrogen-containing bisphosphonates were developed QSAR-models. Established the most likely mechanism anti-candida action of nitrogen-containing bisphosphonates. Results were introduced to the scientific and training processes of the department of acoustics and acoustoelectronics FEL NTU "KPI". Field of application - bioorganic chemistry.

Files

Similar theses