Babich O. Bioactive resorptive calcium silicophosphate glass-ceramic material for bone implants

Research object: processes of obtaining bioactive resorptive calcium silicophosphate glass-ceramic materials. Research purpose: development of compositions and technological parameters of obtaining bioactive resorptive calcium silicophosphate glass-ceramic materials for bone implants. Research methods: IR-spectroscopy, X-ray diffraction analysis, differential scanning calorimetry, gradient-thermal analysis, petrographic analysis, electron-microscopy; X-ray fluorescent, spectrometric and photometric analyses. Theoretical and practical results: resorptive calcium silicophosphate glass-ceramic materials for bone implants have been scientifically substantiated and experimentally obtained via directed crystallization of glasses in conditions of short thermal treatment. Novelty: mechanism of structure and phase formation of glass-ceramic materials obtained by ceramic technology has been established, which consists in consecutive formation of sybotaxic [РО4]3- groups in the melt in case of CаO/P2O5 = 4 ratio, calcium phosphate nucleators by liquation mechanism at cooling and volume fine crystallization of calcium hydroxyapatite and carbon-apatite in the structure of glass ceramic material, and its following thermal treatment has been established. Parameters of formation of apatite-like layer on the surface of resorptive calcium silicophosphate glass-ceramic materials and their mechanical properties, which allows their use at significant bone loads, has been determined. Degree of implementation: under the conditions of State-owned Experimental Prosthetic Orthopedical Enterprise and Certified Laboratory of RETC "Southern Railroad" (Kharkiv), experimental-industrial and experimental-laboratory tests have been successfully carried out. Positive results of clinical and biological tests under conditions of GE "Institute of Pathology of Spine and Joints named after M.I. Sitenko" of AMSU prove viability of the use of obtained glass-ceramic materials as bone implants. Sphere of use: technology of glass-ceramic materials of technical and medical application, particularly of application in military medicine.