Mazur A. Radioimmunologic analysis in prognosis of hemablostosis course

Dissertation is devoted to improving the prognosis of AML, ALL and CHLL, assess the effectiveness and further monitoring of treatment for leukemia data based on the determination of TC and ?2-MCG in blood serum by RIA. The results of dynamic studies of TC and ?2-MCG in 220 adult patients with leukemia aged 17 to 78 years: 97 with AML, 36 with ALL, 87 CHLL. Established that they values of initial TC and ?2-MCG patients with leukemia may be divided into prognostic groups to establish the probable duration of survival, monitoring and treatment stratification, using more intensive remission induction chemotherapy scheme developed for resistant forms. Specifically, for patients with AL TC values at more than 20.0 U/l in patients with CHLL - 30.0 U/l an data level of ?2-MCG exceeding 10.0 mg/l in all cases. Proved that patients with AML, ALL and CHLL had the high east survival in achieving a complete remission with a minimum initial concentrations of these TM: TC - to 10.0 U/l and ?2-MCG to 5.0 mg/l. On the dynamics of the content of TC and ?2-MCG in remission may anticipate the threat of recurrence and time louse of appropriate medical tactics