Mykulyak V. The differentiated use of metabolic therapy in patients with acute myocardial infarction and comorbidities.

The thesis is dedicated to the increase of efficiency of treatment acute myocardial infarction in case of comorbidity with arterial hypertension and diabetes mellitus type 2 by additional to standard therapy differential administration of L-arginine and quercetin. The main peculiarities of clinical and functional course of acute myocardial infarction in patients with hypertension and diabetes mellitus type 2 were set. Established that more severe course of acute myocardial infarction in case of comorbidity deals with larger mass of necrosis, intensive resorption-necrotic syndrome, higher incidence of vitally dangerous complications and early development of pathological left ventricle remodeling. Efficiency and expediency of application of nitric oxide donor L-arginine in patients with acute myocardial infarction and arterial hypertension, diabetes mellitus type 2 and bioflavonoid quercetin in patients with acute myocardial infarction without concomitant pathology were set. Differential approaches of administration L-arginine and quercetin allows to correct basic clinical, laboratorial syndromes and to improve 2-year survival of patients with acute myocardial infarction in case of comorbidity.