Gudz E. The protective action of N-stearoylethanolamine under the influence of doxorubicin for Lewis carcinoma in mice.

For the first time, we studied the ability of saturated NAE 18: 0 - N N-stearoylethanolamine to prevent toxic effects in mammalians, arising from Lewis carcinoma and the administration of doxorubicin. For the first time it was shown that the administration of N-stearoylethanolamine can normalize levels of blood urea and creatinine, increased because of the development of the tumor and administration of doxorubicin. NSE leads to reduction in toxic effects of doxorubicin on the tissues of heart and liver, as seen from its ability to prevent the rise in the activity of aspartate aminotransferase and alanine aminotransferase in blood plasma. We established that administration of NSE modulates the activity of antioxidative enzymes in the tissues of heart, liver and kidneys, unbalanced by the action of doxorubicin, administrated during the growth of the tumor. We showed that NSE is capable of modulating the production of interleukins (TNF?, IL-10) in mice having Lewis carcinoma under the influence of doxorubicin. We showed for the first time that in male mice, NSE immobilised on polyvinylpyrrolidone together with doxorubicin has no impact upon the latter's cytostatic effects, but results in reduction of its toxic effects on conditionally normal tissues.