Goncharova J. Clinical and Genetic Grounding of the Complex of Preventive Measures in Preterm Infants with Bronchopulmonary Dysplasia.

The dissertation has centred on the optimization of prognosis and prevention of BPD in preterm infants through the development of clinical predictive models of development of diseases at different ages, the study of the contribution of polymorphism genes glutathione-S-transferases family and phonospirographic respiratory changes in the development of BPD, its course, and early and long-term outcomes of treatment. The facts that significantly associated with the development of BPD were identified and clinical predictive models for рreterm іnfants at different ages were designed on their basis. The impact of GSTM1 gene on the development of BPD, deletion polymorphism of GSTT1 gene on the duration of mechanical ventilation, and the impact of combinations of polymorphic genes GSTM1 and GSTP1 the development of late infections, which are significant risk factors for development of BPD, were proved. At 24 months adjusted age 66,7 % of children have the psycho-emotional development retarding, 27,27 % speech development retarding, and 9,08 % static-kinetic development retarding and significant effect of mechanical ventilation duration on psycho-emotional development of children was also proved. GST gene polymorphism has no impact the development of children with BPD and also on their increased incidence of acute upper respiratory tract infection during the first two years of life. Optimization system model of care for children with BPD was designed and its effectiveness was proved.