Research object: the process of diagnosis efficiency of production and business enterprises of domestic machine-building enterprises; Purpose: further development of theoretical positions, methods of practical recommendations for implementation and use of the results of diagnostics efficiency of production and economic activity; research method and apparatus, abstract logical method, system approach, methods of analysis and synthesis, graphical method, tools of descriptive statistics, method of canonical analysis, factor analysis, optimization method, the economic analysis; Theoretical and practical results: a methodical approach to diagnosis efficiency of production and business enterprises, which difference is the content, sequence of steps and instruments; meaningful definition of industrial and economic efficiency of the company, which is formed by three components: efficiency subsystems industrial and business enterprises, efficiency of fixed resources, the social and environmental performance; Methodical provision on choosing the most contemporary trend of industrial and economic activity of the enterprise by building a structural model that determines the direction of growth, support or conversion subsystems industrial and economic activities, identification of which is based on a comparative analysis of the interval of changes in diagnostic efficiency components of industrial and economic activity Rating state and its subsystems; the meaning of "diagnosis" which, unlike the existing ones, provides: objective identification of the object in real time and spatial dimensions; comparing the results achieved with optimal; identify causal mechanisms to address "bottlenecks" and reserves development; forecasting major trends; methodical approach to the development of incentive measures to improve production and economic activities, taking into account the interests of groups of workers as managers senior and middle managers and workers of the main production enterprises and workers that serve basic processes of industrial and economic activity; System parameters that determine the efficiency of production and economic activity components and provide performance criteria such as commitment, optimality and efficiency; subject matter and degree of implementation: design implemented in practice JSC "Kharkiv transport equipment plant", LLC "Petrometal Ukraine" Simon Kuznets Kharkiv National University of Economics in teaching discipline "Banking"; Scope: industrial and economic activity of the enterprise, the educational process.