Rudenko S. Viral infection and sensitization in children during the first six years of life of patients with obstructive bronchitis and bronchial asthma and ways of their correction.

The dissertation has centred on the of early diagnosis of asthma in children, improve the efficiency of therapeutic and preventive measures based on the study of viral infection, risk factors, clinical and pathogenetic studies, immunological and functional parameters. For the first time using respirosonographyc complex in children first 6 years of bronchial obstruction assessed violations airway. The high levels of IL-13 in serum of children with recurrent episodes of obstructive bronchitis, which was significantly higher than in healthy children and significantly is different from the contents of the same index in children with asthma. Established the efficacy of H1-antihistamine 2nd generation in complex therapy of children with recurrent episodes of obstructive bronchitis and asthma diagnosed with fungal sensitization to allergens and household. Proved the clinical efficacy of early administration of anti-inflammatory drug montelukast sodium antyleykotriyen action in children with recurrent episodes of obstructive bronchitis. Proved high efficiency of ribosomal vaccine in children with infectious and caused by bronchial obstruction.