Dolovaniuk V. New fluorinated analogs of ornithine, glutamic acid, proline and there derivatives

Fluoroalkyl substituted analogs of natural amino acids. Development of methods of synthesis of polyfluoroalkyl substituted analogs of glutamine/ornithine, pyroglutamic/proline, analogs of thalidomide. Catalytic reduction of intermediate heterocyclic compounds is the key stage in synthesis analogs of natural amino acids. Chemical synthesis, IR- and NMR-spectroscopy, column, charge-transfer , paper chromatography. There were developed affective synthetic routes of 5-trifluoromethyl proline, potentially biologically active analogs of thalidomide. New b-polyfluoroalkyl-b-hydroxyl-a-amino acids were synthesize, new b-trifluoromethyl substituted a,b-diamino acids were obtained. Sphere of use - bioorganic chemistry.