Cherednikova T. Lipid surfactant metabolites in diagnostics and prognosing of pneumonia's course in children and optimization of their therapy

The dissertation dedicated to contemporary study of clinical-paraclinical peculiarities of pneumonia in children and devoted to determination of markers of inflammation process and surfactant damage according to indices of lipids, products of their peroxidation and antioxidant protection in children’ expirate during non-clinical pneumonia. The dynamic of mentioned metabolites of pneumonia in children aged 4-17 years have been examined, depending on the form of pneumonia, period of disease, the severity of inflammatory process and existing complications, the characteristics of disease flow. It was proved their diagnostic and prognostic value. The diagnostic algorithm based on indices change of lipids, products of their peroxidation and antioxidant protection in children’ expirate with non-clinical pneumonia was devised. The substantiated block-diagram of pathogenesis for prolonged course of pneumonia at contemporary stage was scientifically defined. The prediction algorithm of prolonged pneumonia development in children was created, based on analysis of clinical, laboratory, instrumental data. In the thesis was scientifically proved the possibility, practicality and efficiency of surfactant-protective therapy application, i.e. morpholinio-methyl-triazolin-thioacetate, which has a membrane stabilization effect and antioxidant properties, in combination with basic treatment in children with pneumonia from high-risk group for prevention of complications development and prolonged course of the disease.