Riaboshapka A. Features of passing and treatment of squamose cell carcinomas of oral cavity and oropharynx, associated with human papillomavirus

128 patients with locally advanced squamous cell carcinoma of the oral cavity and oropharynx (stage III, IVA, IVB), treated at CI "Zaporizhzhia regional clinical oncology dispensary" RC from 2008 to 2011 were included in to the study. HPV types 16 and 18 are present in carcinomas of the oral cavity and oropharynx in 46.9 of cases. The basic group consisted of 60 patients with HPV-positive tumors. The comparison group included 68 patients with HPV-negative tumors. 31 patients (51.7%) from basic and 34 patients (50.0%) from the comparison group during the RT received injections of recombinant IFN-а2b. The effectiveness of induction CT followed RT in patients with HPV-associated carcinomas is higher, compared to patients with HPV-negative tumors: objective response rate to treatment 79.3% vs. 55.8% respectively, median of progression-free survival 7 months vs. 2.5 months respectively, one-year survival rate 58.6 % vs. 32.4 % respectively, median of overall survival 13.5 months vs. 8 months respectively. Using IFN-а2b concomitantly with RT can achieve better results in patients with HPV-associated carcinoma: objective response rate 83.9% vs. 58.9%, median of progression-free survival 7 months vs. 3 months; one-year survival rate 80.7% vs. 41.2%, two-year survival rate 41.9% vs. 11.8%, median of overall survival 17 months vs. 11 months compared to patients with HPV-negative tumors.