Khromykh K. Vasoregulating vascular endothelial functionin children with allergic asthma and pharmacological correction of it's disturbances

Dissertation is devoted to the study of vasoregulatory vascular endothelial function disorders in children with allergic asthma, by determination the role of homocysteine, vascular endothelial growth factor (VEGF) and basic anti-inflammatory therapy in the pathogenic mechanisms of their formation. It's proved that in children with allergic asthma, has been a vasoregulating vascular endothelial function disturbances, which manifested itself in the growth of serum homocysteine and VEGF, but also by changes in ultrasonography of the carotid and brachial arteries, which are directly dependent on the severity and the level of the disease control. On the basis of changes in laboratory and instrumental markers of endothelial dysfunction has been found effects of anti-inflammatory therapy on vascular endothelial dysfunction. It's proved that in patients who received inhaled corticosteroids were significantly more frequently observed elevated levels of homocysteine and VEGF in serum and ultrasonographic changes. The occurrence of side effects of the inhaled corticosteroids treatment had a dose-dependent effect and depended on the delivery device. Based on these results was proposed correction of vasoregulatory vascular endothelial function disorders by L-arginine in children with allergic asthma treated with inhaled glucocorticoids. Noted the positive dynamics in the group of patients which treated with L-arginine (an improvement of the clinical picture and the control level, decrease of serum homocysteine and VEGF, normalization of ultrasonographic parameters).