Konovalova N. The prognostic significance of eNOS gene polymorphism and homocysteine levels in the progression of hypertension in adolescents with diencephalic syndrome of puberty

The work is devoted to the improvement of early diagnosis and determine the predictors of progression of arterial hypertension, the development of left ventricular myocardial remodeling in adolescents with diencephalic syndrome of puberty. Characteristic changes at the level of homocysteine in the blood serum are increasing the average systolic and diastolic blood pressure, the index increased diastolic blood pressure during the night High homocysteine levels is associated with elevated levels of catecholamines, variability changes in systolic and diastolic blood pressure, with indicators of geometric and functional remodeling of the left ventricular myocardium. The study of gene polymorphism of endothelial nitric oxide synthase (eNOS) found that genotype 4a/4a is unfavorable with respect to the development of metabolic disorders and is characterized by the highest rates of insulin (p <0,05), very low density lipoproteins (p <0,05) and triglycerides ( p <0,05). For teenagers, carriers of allele b, characterized by the development of concentric left ventricular remodeling myocardium (p <0.05), for carriers of allele a - LV myocardial remodeling by type concentric hypertrophy. The prognostic risk stratification models for progression of hypertension in adolescents with hypothalamic syndrome of puberty was developed.